Research Interests
We focus on the suprachiasmatic nucleus (SCN) of the hypothalamus,
a brain region that is required for circadian rhythms in mammals.
Clock in a dish.
Some neurons can keep 24h time in culture.
They are electrically active for a part of each day.
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Current projects include:
- Which cells are responsible for pacemaking?
- Are these cells unique in their pacemaking abilities?
- How do these cells coordinate their activities to drive behavior?
We study the circadian properties of cells in isolation,
in small networks, and from different brain and body tissues.
By combining behavioral assays,
cell culture, electrophysiological
and molecular techniques, we examine the intracellular and
intercellular processes that are involved in rhythm generation,
synchronization to the environment, synchronization among
oscillators and rhythmic output.
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